Plasmid-Mediated Co-Occurrence of <i>mcr-1.1</i> in Extended-Spectrum <i>β</i>-Lactamase (ESBL)-Producing <i>Escherichia coli</i> Isolated From the Indigenous Seminomadic Community in Malaysia.

ABSTRACT: The growing prevalence of commensal antibiotic resistant Escherichia coli poses a significant concern for the global spread of antibiotic resistance. Stool samples (n = 35) from a seminomadic indigenous community in Malaysia, the Jehai, were screened for multidrug-resistant bacteria, specifically the extended-spectrum β-lactamase (ESBL) producers. Subsequently, whole-genome sequencing was used to provide genomic insights into eight ESBL-producing E. coli that colonised eight individuals. The ESBL E. coli isolates carry resistance genes from various antibiotic classes such as the β-lactams (bla _TEM, bla _CTX-M-15 and bla _CTX-M-55), quinolones (gyrA, qnrS and qnrS1) and aminogl

SUBMITTER: Yap PSX 

PROVIDER: S-EPMC12017022 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature