Extremely Early Appearance of Islet Autoantibodies in Genetically Susceptible Children.

ABSTRACT:

Objective

We studied the characteristics of children who developed islet autoantibodies by the age of 0.50 years and hypothesized that the appearance of extremely early islet autoimmunity differs between four birth cohorts within 1994-2019 according to the change in the incidence of Type 1 diabetes (T1D) in Finland.

Methods

Data from Finnish children participating in the Type 1 Diabetes Prediction and Prevention (DIPP) study, or the Environmental Determinants of Diabetes in the Young (TEDDY) study were analyzed. These studies follow children with increased HLA-conferred risk for T1D with regular measurements of islet autoantibodies. Maternally transferred antibodies were excluded by comparing islet autoantibodies in cord serum, child's first follow-up serum and the maternal

SUBMITTER: Kyronniemi A 

PROVIDER: S-EPMC12017086 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature