First WGS Characterization of <i>Streptococcus suis</i> Isolated From a Case of Human Meningitis in Southern Italy.

ABSTRACT: This study is the first report in Italy on the molecular characterization by whole-genome sequencing (WGS) analysis of a Streptococcus suis strain isolated from a human case of meningitis in Italy. The characterized S. suis strain was classified as a serotype 2 (SS2), multilocus sequence typing (MLST) sequence type ST1. The strain exhibited the presence of several virulence genes and resistance to penicillin, tetracycline and macrolide-lincosamide-streptogramin. Finally, we found a frameshift mutation in the gene mrp determining the translation of two truncated forms of the corresponding muramidase-release protein. These results highlight the importance of complete genomic data to understand the pathogenesis and epidemiology of this bacterium, capable to pose serious r

SUBMITTER: Fusco G 

PROVIDER: S-EPMC12017127 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature