A RFLP 1-4-3 L1C Variant of PRRSV-2 Isolated in Sichuan Province, China: Genetic Characterization and Pathogenicity.

ABSTRACT: Porcine reproductive and respiratory syndrome virus (PRRSV), known for causing reproductive disorders in sows and respiratory issues in piglets, poses a significant threat to the global swine industry. Since its initial report in 2013, the L1C (lineage 1.8/NADC30-like) PRRSV has drawn significant attention in China due to its high recombination potential and diverse pathogenicity. This study focuses on a naturally occurring recombinant L1C variant, SCABTC-202302, characterized by an restriction fragment length polymorphism (RFLP) pattern of 1-4-3. We investigate the strain's genetic evolution, recombination, pathogenicity, and immune and antibody responses. Phylogenetic analysis of the ORF5 (open reading frame) gene classified the SCABTC-202302 strain as lineage 8.7, while whole-genome ana

SUBMITTER: Deng LS 

PROVIDER: S-EPMC12017144 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature