Carbapenemase-Producing Enterobacterales: An Increasing Threat to Australian Liver Transplant Recipients.

ABSTRACT:

Introduction

Carbapenemase-producing Enterobacterales (CPE) are associated with increased morbidity and mortality in liver transplant recipients (LTRs). There is a paucity of data regarding CPE colonization and infection in Australian LTRs.

Methods

A single-center retrospective cohort study of CPE was performed in LTRs from 2015 to 2024. LTRs underwent targeted screening and a period of enhanced screening to evaluate the incidence of CPE colonization. CPE infections were identified via clinical samples. All CPE isolates underwent whole genome sequencing. CPE isolation rates in LTRs were compared to the general hospital population and trends over time were analyzed.

Results

There were 31 episodes of CPE isolation (5 community acquired, 26 healthcare associated) from 28

SUBMITTER: Kamaladasa D 

PROVIDER: S-EPMC12017315 | biostudies-literature | 2025 Mar-Apr

REPOSITORIES: biostudies-literature