A molecularly defined mPFC-BLA circuit specifically regulates social novelty preference.

ABSTRACT: Social novelty preference is an important aspect of social interaction for evaluating new threats and opportunities for survival, but the underlying neuronal mechanism remains unclear. Here, we identify a molecularly defined medial prefrontal cortex (mPFC) excitatory neuron subtype, located in layer 5 expressing Il1rapl2, which is highly associated with social deficit disorders in genome-wide association studies and might be responsible for regulating social novelty preference. Using an Il1rapl2-Cre mouse line, we show that chemogenetic activation of the mPFC Il1rapl2-expressing neurons impairs social novelty preference but with little effect on sociability. In addition, fiber photometry recording indicates that this neuron subtype is inhibited when mice interact with

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12017316 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature