Functional Brain Connectivity Predictors of Prospective Substance Use Initiation and Their Environmental Correlates.

ABSTRACT:

Background

Early substance use initiation (SUI) places youth at substantially higher risk for later substance use disorders. Furthermore, adolescence is a critical period for the maturation of brain networks, the pace and magnitude of which are susceptible to environmental influences and may shape risk for SUI.

Methods

We examined whether patterns of functional brain connectivity during rest (rsFC), measured longitudinally during pre- and early adolescence, can predict future SUI. Next, in an independent subsample, we tested whether these patterns were associated with earlier environmental exposures, specifically neighborhood pollution and socioeconomic dimensions. We utilized data from the ABCD (Adolescent Brain Cognitive Development) Study. SUI was defined as first-time us

SUBMITTER: Kardan O 

PROVIDER: S-EPMC12017335 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature