Disrupted functional connectivity of the emotion regulation network in major depressive disorder and its association with symptom improvement: A multisite resting-state functional MRI study.

ABSTRACT:

Background

The emotion regulation network (ERN) in the brain provides a framework for understanding the neuropathology of affective disorders. Although previous neuroimaging studies have investigated the neurobiological correlates of the ERN in major depressive disorder (MDD), whether patients with MDD exhibit abnormal functional connectivity (FC) patterns in the ERN and whether the abnormal FC in the ERN can serve as a therapeutic response signature remain unclear.

Methods

A large functional magnetic resonance imaging dataset comprising 709 patients with MDD and 725 healthy controls (HCs) recruited across five sites was analyzed. Using a seed-based FC approach, we first investigated the group differences in whole-brain resting-state FC of the 14 ERN seeds between participan

SUBMITTER: Lan Z 

PROVIDER: S-EPMC12017356 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature