Development of a core outcome set for clinical trials targeting interventions aiming to improve adherence to appropriate polypharmacy in older people-an international consensus study.

ABSTRACT:

Background

Medication non-adherence is prevalent in older people taking polypharmacy. Several interventions have been employed to improve adherence in this population. However, inconsistencies in outcomes have impeded comparisons of findings. Accordingly, this work aimed to develop a core outcome set (COS) for use in trials aiming to improve adherence to appropriate polypharmacy in older people.

Methods

A group of stakeholders, including academics, journal editors, healthcare professionals (HCPs) and public participants, evaluated 13 outcomes compiled from the literature in a Delphi study using a nine-point Likert scale ranging from 1 to 9, where higher scores (7-9) indicated critical importance and lower scores (1-3) unimportance. The resultant Delphi consensus list was dis

SUBMITTER: Al Shaker H 

PROVIDER: S-EPMC12017393 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature