Methylome and transcriptome analyses reveal HLA-DMB's contribution to periodontitis development.

ABSTRACT:

Background

Periodontitis is a typical oral disease. Polymorphonuclear neutrophils (PMNs) are crucial immune cells in periodontal tissues, relating to infection, inflammation, and innate immunity. We herein aimed to explore important periodontitis PMN related genes.

Methods

Periodontitis and control samples were downloaded from Gene Expression Omnibus database, including GSE173082 (methylation data, n=72), GSE10334 (n=127), GSE43525 (n=23), GSE16134 (n=134). Differential expression analysis and differential methylation analysis was employed to find candidate genes. Receiver operating characteristic analysis was performed to evaluate the diagnostic value of the hub gene. The functional pathways were determined by gene set enrichment analysis. Using CIBERSORT software, the immu

SUBMITTER: Zhao B 

PROVIDER: S-EPMC12017480 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature