Poor sleep and high rheumatoid arthritis risk: Evidence from large UK Biobank cohort.

ABSTRACT:

Objective

To evaluate the relationship between sleep behaviors and rheumatoid arthritis (RA) risk.

Methods

First, based on large-scale data from the UK Biobank, we analyzed the associations between multiple sleep factors and RA risk and calculated a poor sleep score (PSS) to assess their combined effect. Then we constructed genetic risk scores (GRS) based on a large genome-wide association study and assessed the interaction or combined effect of sleep and genetic factors on RA risk. Finally, we conducted a case-control study to explore the effect of RA on sleep.

Results

Sleep duration, getting up, napping during the day, insomnia, and daytime dozing were associated with the risk of RA, but no associations were observed for chronotype and snoring with RA. Participants

SUBMITTER: Yang YQ 

PROVIDER: S-EPMC12017501 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature