The multiscale brain structural re-organization that occurs from childhood to adolescence correlates with cortical morphology maturation and functional specialization.

ABSTRACT: From childhood to adolescence, the structural organization of the human brain undergoes dynamic and regionally heterogeneous changes across multiple scales, from synapses to macroscale white matter pathways. However, during this period, the developmental process of multiscale structural architecture, its association with cortical morphological changes, and its role in the maturation of functional organization remain largely unknown. Here, using two independent multimodal imaging developmental datasets aged 6-14 years, we investigated developmental process of multiscale cortical organization by constructing an in vivo multiscale structural connectome model incorporating white matter tractography, cortico-cortical proximity, and microstructural similarity. By employing the gradient mapping m

SUBMITTER: He Y 

PROVIDER: S-EPMC12017512 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature