Cell-type-specific firing patterns in a V1 cortical column model depend on feedforward and feedback-driven states.

ABSTRACT: Stimulation of specific cell groups under different network regimes (e.g., spontaneous activity or sensory-evoked activity) can provide insights into the neural dynamics of cortical columns. While these protocols are challenging to perform experimentally, modelling can serve as a powerful tool for such explorations. Using detailed electrophysiological and anatomical data from mouse V1, we built a novel spiking network model of a cortical column, which incorporates pyramidal cells and three distinct interneuron types (PV, SST, and VIP cells, specified per lamina), as well as the dynamic and voltage-dependent properties of AMPA, GABA, and NMDA receptors. We first demonstrate that thalamocortical feedforward (FF) and feedback (FB) stimuli arriving in the column have opposite effects, leading

SUBMITTER: Moreni G 

PROVIDER: S-EPMC12017539 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature