Fibroblasts fluctuating between mesenchyme and epithelium are involved in hair follicle mesenchyme development.

ABSTRACT: The transition between the mesenchyme and epithelium contributes to the development of various tissues. During skin development, epithelial-mesenchymal transition in the ectodermal epithelia is involved in the development of the dermal mesenchyme in early embryos. However, the precise roles and functions of epithelial-mesenchymal/mesenchymal-epithelial transition in cutaneous development have not been fully elucidated. In this study, we aimed to elucidate these roles and functions in the neonatal mouse skin. We conducted single-cell RNA sequencing and immunohistochemical analyses to search for Pdgfra-expressing (Pα ⁺) fibroblasts with transition activities to/from Krt5-expressing keratinocytes. We determined that the Pα ⁺/Krt5-lineag

SUBMITTER: Hirose Y 

PROVIDER: S-EPMC12017859 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature