The clinicopathological implications of serum IL-33 and sST2 as cancer biomarkers: A narrative review.

ABSTRACT:

Background

Interleukin (IL)-33 and its receptor, soluble suppression of tumorigenicity 2 (sST2), are key players in the immune response and cancer biology. IL-33 can promote tumorigenesis by enhancing cancer cell proliferation and modulating the immune environment to support tumor growth. Conversely, it can also bolster anti-tumor immunity by recruiting and activating immune effector cells. IL-33 plays a role in multiple aspects of cancer biology, such as promoting immune evasion, tumor growth, and metastasis.

Objective

This study intends to assess the prognostic significance of serum IL-33 and sST2 in cancer and their association with clinicopathologic characteristics (CPC).

Material & methods

Scopus, PubMed electronic databases and other sources were searched and an

SUBMITTER: Acharya S 

PROVIDER: S-EPMC12018031 | biostudies-literature | 2025 May-Jun

REPOSITORIES: biostudies-literature