Development of ultrasound-visualized tumor-targeting engineered bacteria for precise tumor therapy.

ABSTRACT: In situ imaging diagnosis and precise treatment of deep tumor tissues are hotspots in life sciences and medical research. In recent years, using focused ultrasound to remotely control engineered bacteria for drug release has become one of the methods for precise in vivo drug delivery. However, non-visualized engineered bacteria pose challenges for precise control within the body. Therefore, there is an urgent need for an engineered bacterial vector capable of deep tissue imaging to precisely locate bacteria in vivo. Acoustic reporter genes (ARGs) are biological elements used for deep tissue imaging, with gene clusters over 8 kb. However, ARGs are often tested on plasmids, which hinders stable expression in vivo and limits the space for inserting components that

SUBMITTER: Qu L 

PROVIDER: S-EPMC12018036 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature