Intranasal kisspeptin administration rapidly stimulates gonadotropin release in humans.

ABSTRACT:

Background

Kisspeptin administration by intravenous or subcutaneous routes activates hypothalamic gonadotropin-releasing hormone (GnRH) neurons and is being developed to treat reproductive disorders. However, these invasive routes markedly limit patient acceptability and clinical use. Recent rodent data has identified a large GnRH population within the olfactory system communicating directly with hypothalamic GnRH neurons. Intranasal kisspeptin administration may be able to capitalise on this novel pathway and thus offer a potential non-invasive approach to stimulate reproductive hormones. Herein, we examine intranasal kisspeptin using human, pharmaceutical, and rodent studies.

Methods

Reproductive hormone profiles were measured after intranasal kisspeptin administration in

SUBMITTER: Mills EG 

PROVIDER: S-EPMC12018048 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature