Enhancing ultrasound applications through shell-less nanobubbles: A study on acoustic and optical properties.

ABSTRACT: Histotripsy employs acoustic inertial cavitation to mechanically destroy tissue, producing acellular debris. While introducing bubbles can lower the cavitation threshold and enhance treatment efficiency, micrometer-scale bubbles struggle to penetrate tissues effectively. Shell-less nanobubbles, with their high internal pressure, stability, negatively charged surfaces, and unique lifetimes ranging from weeks to months, offer a promising alternative. However, their interactions with ultrasound remain unexplored. This study used a claw-type pump nanobubble generator to produce nanobubbles and employed acoustic and optical methods to observe their behavior under high-intensity ultrasound exposure. The results demonstrated that the device generated nanobubble solutions with an average particle

SUBMITTER: Hsieh ZH 

PROVIDER: S-EPMC12018085 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature