C3aR1 on β cells enhances β cell function and survival to maintain glucose homeostasis.

ABSTRACT:

Objective

Pancreatic β cell dysfunction is critical to the development of type 2 diabetes (T2D). Our previous studies suggested that C3aR1 on β cells promotes insulin secretion and cell survival. However, as C3aR1 is expressed on many other cell types including within the islets, whole-body C3aR1 knockout models confound the analyses of direct impacts on β cells.

Methods

To clarify the role of C3aR1 in β cells under T2D conditions, we generated β cell-specific C3aR1 knockout mice. We assessed glucose homeostasis, focusing on β cell function and mass under metabolic stress conditions, to interrogate the effects of C3aR1 on β cells in a mouse model of T2D. We performed proteomic analyses on islets from control and β cell-specific C3aR1 knockout mice. To determine potential tra

SUBMITTER: Pereira de Lima R 

PROVIDER: S-EPMC12018202 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature