Sulfhydrated albumin transmits H₂S signaling and ameliorates DOX-induced multiorgan injuries.

ABSTRACT: Hydrogen sulfide (H₂S) is a vital signaling molecule involved in various physiological processes; however, the mechanisms underlying its systemic signaling remain poorly understood. We hypothesized that albumin, the predominant plasma protein and a vital sulfhydryl carrier, mediated systemic H₂S signaling, which could potentially treat H₂S-deficient diseases. This study aimed to investigate this hypothesis. Our results showed the presence of sulfhydrated proteins in normal mouse serum, with albumin being particularly enriched. The level of sulfhydration was influenced by H₂S availability and the redox environment. In vitro incubation of albumin with NaHS resulted in an increased number of sulfhydrated groups. Under reductive conditions, this sulf

SUBMITTER: Xu Y 

PROVIDER: S-EPMC12018206 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature