Persistence and adherence to levodopa adjunct medications in elderly patients with Parkinson's disease: a retrospective cohort study using a Japanese claims database.

ABSTRACT:

Objective

We investigated treatment persistence and adherence for levodopa adjunct medications and their relationship with demographic factors in Japanese patients with Parkinson's disease (PD).

Methods

This longitudinal retrospective study used a Japanese health insurance claims database for levodopa adjunct medications in patients newly prescribed anti-PD drugs other than levodopa between December 2020 and November 2021. Patients with a PD diagnosis were included in this study, and 17 anti-PD drug cohorts were formed. The primary outcomes were treatment persistence and adherence over 1 year. Multivariate analysis was conducted to evaluate demographic factors associated with treatment persistence/adherence.

Results

In total, 7,605 patients were included in this analy

SUBMITTER: Nagai M 

PROVIDER: S-EPMC12018396 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature