HnRNP L is essential for peripheral T cell proliferation and survival.

ABSTRACT:

Introduction

During T cell development, heterogeneous nuclear ribonucleoprotein (hnRNP) L is known to regulate CD4 T helper subset differentiation, the proliferation and migration of thymocytes, as loss of hnRNP L in early T cell development results in a failure of T cells to reach the periphery.

Methods

To better understand the role of hnRNP L in modulating peripheral T cell trafficking and function, we analyzed T survival and activation in newly generated CD4Cre x hnRNP L^Fl/Fl (KO) mice. In vitro and in vivo analyses of CD4 T cell differentiation, T cell proliferation and death post activation were performed.

Results

Our initial study of the steady state profile of the KO mice showed normal migration of T cells from the thymus, but periphera

SUBMITTER: White TLA 

PROVIDER: S-EPMC12018431 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature