Insomnia increases the risk for specific autoimmune diseases: a large-scale retrospective cohort study.

ABSTRACT:

Objective

The global rise of autoimmune diseases presents a significant medical challenge, with inadequate treatment options, high morbidity risks, and escalating healthcare costs. While the underlying mechanisms of autoimmune disease development are not fully understood, both genetic predispositions and lifestyle factors, particularly sleep, play critical roles. Insomnia and circadian rhythm sleep disorders not only impair sleep but also disrupt multi-organ interactions by dysregulating sympathetic nervous system activity, altering immune responses, and influencing neuroendocrine function. These disruptions can contribute to immune system dysregulation, increasing the risk of autoimmune disease development.

Methods

To assess the impact of impaired sleep on the risk of devel

SUBMITTER: Stenger S 

PROVIDER: S-EPMC12018472 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature