Effects of childhood and adult height on later life cardiovascular disease risk estimated through Mendelian randomization.

ABSTRACT: Taller individuals are at elevated and protected risk of various cardiovascular disease endpoints. Whether this is due to a direct consequence of their height during childhood, a long-term effect of remaining tall throughout the lifecourse, or confounding by other factors, is unknown. We sought to address this by harnessing human genetic data from the UK Biobank to separate the independent effects of childhood and adulthood height using an approach known as lifecourse Mendelian randomization (MR). Protective effects of taller childhood height on risk of later life coronary artery disease (OR = 0.78 per change in height category, 95% CI = 0.70 to 0.86, P = 4 × 10^- 10) and stroke (OR = 0.93, 95% CI = 0.86 to 1.00, P = 0.03) using data from large-scale consortia were found using a

SUBMITTER: Richardson TG 

PROVIDER: S-EPMC12018521 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature