Dynamic immune response to Avian Pathogenic Escherichia coli infection in broiler chickens: Insights into pro-inflammatory and anti-inflammatory cytokine regulation: CYTOKINE REGULATION IN APEC INFECTED BROILERS.

ABSTRACT: Avian Pathogenic Escherichia coli (APEC) poses a significant threat to the U.S. poultry industry, causing respiratory infections and systemic colibacillosis. Understanding APEC's impact on the immune response is crucial for developing effective prevention and treatment strategies. This study investigates the dynamic immune responses to APEC infection in broiler chickens, with a focus on survival rates, airsac lesion scores, and cytokine gene expression patterns in lung tissue. Seven-day-old broiler chicks were divided into control and APEC-inoculated groups, with the control group receiving tryptic soy broth and the APEC group receiving 7 × 10^{^7} CFU of APEC via intratracheal inoculation. Survival data included both male and female birds, while airsac lesion score and lung tissue

SUBMITTER: Ye X 

PROVIDER: S-EPMC12018555 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature