Recurrence of autoimmune hepatitis cholestatic variant syndromes after liver transplantation affects graft and patient survival.

ABSTRACT:

Background & aims

A significant proportion of patients with variant syndromes (VSs), namely autoimmune hepatitis/primary biliary cholangitis or autoimmune hepatitis/primary sclerosing cholangitis, require liver transplantation (LT) despite treatment. The frequency of disease recurrence and the effect on graft survival are yet to be clarified. The aim of this international, multicentric, retrospective study is to evaluate the risk factors associated with recurrence and the impact of the disease recurrence after LT on graft and patient survival.

Methods

We evaluated 166 patients undergoing LT for VS in 33 centers in North America, South America, Europe, and Asia. Clinical data before and after LT, biochemical data within the first 12 months after LT, and immunosuppression afte

SUBMITTER: Ronca V 

PROVIDER: S-EPMC12018556 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature