PH/Hyal-responsive vancomycin-loaded chitooligosaccharide nanoparticles for intracellular MRSA infection treatment.

ABSTRACT: Staphylococcus aureus (S. aureus) is recognized as among the most critical bacterial pathogens globally. A significant portion of the complications associated with S. aureus infections arises from its ability to persist inside host phagocytes, particularly macrophages, making the eradication of intracellular S. aureus vital for therapeutic success. Regrettably, many antibiotics exhibit limited penetration into cells, underscoring the necessity for efficient intracellular delivery mechanisms. In this study, vancomycin-loaded chitooligosaccharide nanoparticles (COS@Van) coated with hyaluronic acid (HA), were engineered to function as an active-targeting antibiotic carrier recorded as HA/COS@Van. The HA coating serves as an external shell, which 1) covers the posit

SUBMITTER: Li W 

PROVIDER: S-EPMC12018565 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature