Exploring anterior thalamus functional connectivity with cortical regions in prospective memory with ultra-high-field functional MRI.

ABSTRACT: Prospective memory, or memory for future intentions, engages particular cortical regions. Lesion studies also implicate the thalamus, with prospective memory deterioration following thalamic stroke. Neuroimaging, anatomical and lesion studies suggest the anterior nuclei of the thalamus (ANT), in particular, are involved in episodic memory, with electrophysiological studies suggesting an active role in selecting neural assemblies underlying particular memory traces. Here, we hypothesized that the ANT are engaged in realizing prospectively-encoded intentions, detectable using ultra-high-field strength functional MRI. Using a within-subject design, participants (N = 14; age 20-35 years) performed an ongoing n-back working memory task with two cognitive loads, each with and without a pr

SUBMITTER: Flanagan L 

PROVIDER: S-EPMC12018800 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature