A system genetics analysis uncovers the regulatory variants controlling drought response in wheat.

ABSTRACT: Plants activate a variable response to drought stress by modulating transcription of key genes. However, our knowledge of genetic variations governing gene expression in response to drought stress remains limited in natural germplasm. Here, we performed a comprehensive analysis of the transcriptional variability of 200 wheat accessions in response to drought stress by using a systems genetics approach integrating pan-transcriptome, co-expression networks, transcriptome-wide association study (TWAS), and expression quantitative trait loci (eQTLs) mapping. We identified 1621 genes and eight co-expression modules significantly correlated with wheat drought tolerance. We also defined 620 664 and 654 798 independent eQTLs associated with the expression of 17 429 and 18 080 eGenes under normal a

SUBMITTER: Chen B 

PROVIDER: S-EPMC12018837 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature