Distinct immune responses in people living with HIV following SARS-CoV-2 recovery.

ABSTRACT:

Background

SARS-CoV-2 infection results in greater disease severity among immunocompromised individuals compared to healthy individuals. However, there is conflicting information about the impact of chronic HIV infection on immune responses to SARS-CoV-2 infection and vaccination.

Method

We used a combination of machine learning approaches and network analysis to explore 56 immune markers and comprehensively profile humoral and cellular immunity in a cross-sectional observational cohort of people without HIV (PWOH; n = 216) and people living with HIV (PLWH; n = 43) who recovered from SARS-CoV-2 infection (13-131 days since SARS-COV-2 diagnosis) early in the pandemic.

Results

PLWH recovered from symptomatic outpatient COVID-19 exhibit lower humoral and B cell responses

SUBMITTER: Mielke D 

PROVIDER: S-EPMC12018938 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature