Polarization-independent regulation of the subcellular localization of Yes-associated protein 1 during preimplantation development.

ABSTRACT: Cell polarization is a crucial developmental process that determines cell differentiation in mouse embryos. During this process, an extensively expressed transcriptional regulator, Yes-associated protein 1 (YAP1), is localized either to the cytoplasm or to the nucleus via HIPPO signaling. In mouse premorula embryos, YAP1 is present in the nuclei of all cells. Thereafter, YAP1 is distributed to the nuclei of outer cells or cytoplasm of inner cells, depending on the establishment of cell polarity and morula formation. However, the dynamics of YAP1 localization in other species, including ruminants, remain unclear. To gain an in-depth understanding of cell differentiation in mammalian embryos, we investigated YAP1 localization changes in bovine embryos. Unlike in mouse morulae, YAP1 displayed

SUBMITTER: Saito S 

PROVIDER: S-EPMC12018982 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature