Genome-Wide DNA Methylation Markers Associated With Metabolic Liver Cancer.

ABSTRACT:

Background and aims

Metabolic liver disease is the fastest-rising cause of hepatocellular carcinoma (HCC), but the underlying molecular processes that drive HCC development in the setting of metabolic perturbations are unclear. We investigated the role of aberrant DNA methylation in metabolic HCC development in a multicenter international study.

Methods

We used a case-control design, frequency-matched on age, sex, and study site. Genome-wide profiling of peripheral blood leukocyte DNA was performed using the 850k EPIC array. The study sample was split 80% and 20% for training and validation. Cell type proportions were estimated from the methylation data. Differential methylation analysis was performed adjusting for cell type, generating area under the receiver-operating char

SUBMITTER: Antwi SO 

PROVIDER: S-EPMC12019016 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature