Effect of GIP and GLP-1 infusion on bone resorption in glucose intolerant, pancreatic insufficient cystic fibrosis.

ABSTRACT:

Context

Diabetes and bone disease are common in cystic fibrosis (CF) and primarily occur alongside exocrine pancreatic insufficiency (PI). "Incretins," glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1), augment insulin secretion and regulate bone metabolism. In CF, PI dampens the incretin response. Loss of the insulinotropic effect of GIP in CF was recently identified, but effects on bone are unknown.

Objective

Determine effects of incretins on bone resorption markers in adults with PI-CF.

Design

Secondary analysis of a mechanistic double-blinded randomized placebo-controlled crossover trial including adults ages 18-40 years with PI-CF (n = 25).

Intervention

Adults with PI-CF received either GIP (4 pmol/kg/min) or GLP-1 (1.5

SUBMITTER: Lei WS 

PROVIDER: S-EPMC12019020 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature