Perfusion Pressures and Weight Loss During Normothermic Machine Perfusion of Human Donor Livers.

ABSTRACT:

Background

Normothermic machine perfusion (NMP) is increasingly used to preserve and assess donor livers prior to transplantation. Due to its success, it is expected that more centers will start using this technology. However, NMP may also cause adverse effects.

Methods

In this retrospective, observational study, we investigated the effect of NMP pressures on donor liver weight, post-transplant outcomes, and hepatic perfusion characteristics. A total of 36 livers were transplanted after NMP. NMP perfusion pressure settings were lowered from a median (IQR) of 47 mmHg (42-54) to 34 mmHg (30-39) for the hepatic artery (HA), and from 8 mmHg (7-10) to 7 mmHg (6-8) for the portal vein (PV) to diminish potential edema formation inside the liver.

Results

This change appeared

SUBMITTER: Lascaris B 

PROVIDER: S-EPMC12019101 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature