Methylphenidate promotes a frontoparietal-dominant brain state improving cognitive performance: a randomized trial.

ABSTRACT: Methylphenidate (MP) is a widely used stimulant medication for the treatment of attention deficit hyperactivity disorder that enhances brain dopamine signaling and improves attention. However, how dopamine stimulation alters brain state dynamics to support improved attention during task performance is still unclear. To address this, we employed a multimodal neuroimaging approach combining positron emission tomography, functional magnetic resonance imaging, and behavioral tasks, to discover associations between dopamine signaling, brain dynamics, and cognition. Multimodal images were collected from 37 healthy adults under a single-blind, counterbalanced, placebo-controlled crossover study. Dynamic functional analysis was used to compare the alterations in dynamic features of brain states be

SUBMITTER: Yan W 

PROVIDER: S-EPMC12019111 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature