Preclinical SC and IV repeat-dose toxicology of a cowpea mosaic virus - A cancer immunotherapy candidate.

ABSTRACT: Cancer immunotherapies focus on boosting the immune system to recognize and eliminate tumor cells. Amongst the various biologics under development for cancer immunotherapy, our team has focused on the study of plant viruses in this context. We have shown that intratumoral administration of cowpea mosaic virus (CPMV) relieves the immunosuppressive tumor microenvironment and elicits a potent, systemic and durable anti-tumor immune response. The potency of CPMV has been demonstrated in several tumor mouse models and in companion canine cancer patients. Toward clinical development, we here studied the pharmacology and safety of CPMV. The repeat-dose toxicity of CPMV was evaluated in female Sprague Dawley rats. Rats received three weekly treatments (subcutaneous or intravenous) of a fixed dose

SUBMITTER: Stern ST 

PROVIDER: S-EPMC12019203 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature