Brain functional abnormality in drug naive adolescents with borderline personality disorder during self- and other-reflection.

ABSTRACT: A disturbed sense of identity is one of the major features of borderline personality disorder (BPD), which manifests early in the course of the disorder, and is potentially examinable using functional imaging during tasks involving self-reflection. Twenty-seven medication-naïve adolescent female patients with BPD, who had no psychiatric comorbidities, and 28 matched healthy female controls underwent fMRI while answering questions either about themselves or acquaintances. Control conditions consisted of answering questions involving factual knowledge and a low-level baseline (cross fixation). When self-reflection was compared to fact processing, BPD patients exhibited reduced activation in the right dorsolateral prefrontal cortex (DLPFC), as well as in the left parietal and calcarine cortex

SUBMITTER: Salgado-Pineda P 

PROVIDER: S-EPMC12019248 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature