Efficacy of Urine Asymmetric Dimethylarginine Concentration to Predict Azotemia in Hyperthyroid Cats After Radio-Iodine Treatment.

ABSTRACT:

Background

Hyperthyroidism can mask concurrent chronic kidney disease in cats, and no accurate biomarkers are available to predict which cats will develop renal azotemia after radioiodine (¹³¹I) treatment.

Hypothesis/objectives

To evaluate the potential of serum and urinary metabolites and metabolite ratios to predict post-¹³¹I renal azotemia in hyperthyroid cats.

Animals

Hyperthyroid cats (n = 31), before and (3-12 months) after treatment with ¹³¹I at the Faculty of Veterinary Medicine (Ghent University, Belgium).

Methods

Retrospective study. Optimized and validated feline extraction and analysis protocols were employed for metabolic profiling of urine and serum samples using ultra-high performance liquid chromatography-high-re

SUBMITTER: Vanden Broecke E 

PROVIDER: S-EPMC12019304 | biostudies-literature | 2025 May-Jun

REPOSITORIES: biostudies-literature