Effect of electromagnetic field radiation on transcriptomic profile and DNA methylation level in pig conceptuses during the peri-implantation period.

ABSTRACT: Extremely low-frequency electromagnetic field (ELF-EMF) radiation alters the steroidogenic activity of porcine conceptuses during the peri-implantation period. This study investigated whether short exposure (2 h) to ELF-EMF radiation may induce changes in the transcriptomic profile of conceptuses and their DNA methylation levels, with a focus on the promoter regions of differentially expressed genes of interest. Porcine conceptuses were collected on days 15-16 of pregnancy, preincubated, and then exposed in vitro to ELF-EMF at a frequency of 50 Hz. ELF-EMF treatment affected the expression of 21 protein-coding transcripts, including solute carrier family 34 member 1 (SLC34A1), hydroxysteroid 17-beta dehydrogenase 2 (HSD17B2), apolipoprotein M (APOM), regucalcin (RGN), heat shock protein fa

SUBMITTER: Franczak A 

PROVIDER: S-EPMC12019412 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature