Multiplateau Force-Extension Curves of Long Double-Stranded DNA Molecules.

ABSTRACT: When highly stretched, double-stranded DNA exhibits a plateau region in its force-extension curve. Using a bead-spring coarse-grained dynamic model based on a nonconvex potential, we predict that a long double-stranded DNA fragment made of several consecutive segments with substantially different plateau force values for each segment will exhibit multiple distinct plateau regions in the force-extension curve under physiologically relevant solvent conditions. For example, a long composite double-stranded (ds) DNA fragment consisting of two equal-length segments characterized by two different plateau force values, such as the poly(dA-dT)-poly(dG-dC) fragment, is predicted to exhibit two distinct plateau regions in its force-extension curve; a long composite dsDNA fragment consisting of three

SUBMITTER: Afanasyev AY 

PROVIDER: S-EPMC12019427 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature