Circulating tumor DNA monitoring in advanced mutated melanoma (LIQUID-MEL).

ABSTRACT:

Introduction

Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of metastatic melanoma, but a percentage of patients did not show benefit. Circulating tumor DNA (ctDNA) has emerged as a potential non-invasive tool for monitoring disease evolution and treatment response. The present study aimed to evaluate the clinical utility of ctDNA dynamics in patients with metastatic melanoma receiving ICIs, while exploring its role in the oncological course.

Materials and methods

The LIQUID-MEL study is a prospective, single-centre pilot study including patients with BRAF/NRAS-mutant metastatic melanoma. ctDNA was quantified using digital droplet PCR (ddPCR) at four different time points. Uni- and multivariable Cox regression models were used to assess the corr

SUBMITTER: Gianmarco M 

PROVIDER: S-EPMC12019447 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature