Allosteric Inhibitors of Cell-Cycle-Regulated Methyltransferase for Novel Antibiotic Development.

ABSTRACT: Cell-cycle-regulated methyltransferase (CcrM) plays a crucial role in regulating important cellular processes that are essential for proper cell division and growth; disruptions of these processes can attenuate the bacteria's viability. Notably, CcrM homologs are present across a set of diverse human pathogens, suggesting that selective inhibition of CcrM over human DNA methyltransferases (DNMT's) could offer a new strategy for combating human bacterial pathogens, leading to the development of novel antibiotics. Herein, we report the screening of two open-access chemical libraries-the National Cancer Institute Developmental Therapeutic Program Diversity Set VII and Medicines for Malaria Venture Global Health Priority Box-and identified four structurally diverse inhibitors of CcrM. Among th

SUBMITTER: Hernandez I 

PROVIDER: S-EPMC12019475 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature