Estrogen Inhibits the Phenotypic Switching of Vascular Smooth Muscle Cells through ER-α/CREB in Aortic Dissection.

ABSTRACT: Objective: To examine the alterations in estrogen levels in patients with aortic dissection (AD) and its protective effect on AD patients through the inhibition of vascular smooth muscle cells (VSMCs) phenotypic switching via the ER-α/CREB pathway. Methods: Demographic data were collected to assess sex disparity in AD patients, and serum 17β-estradiol (E2) levels were measured using ELISA. Phenotypic switching markers were analyzed in aortic tissues from AD patients and controls. Bioinformatics analysis identified estrogen-related pathways, focusing on the ER-α/CREB axis, with expression levels confirmed via immunohistochemistry and Western blot. AD mouse models were developed in male and ovariectomized female mice, with the effects of E2 supplementation on AD progression and

SUBMITTER: Pu Y 

PROVIDER: S-EPMC12019514 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature