Detection Bias in EHR-Based Research on Clinical Exposures and Dementia.

ABSTRACT:

Importance

Detection bias occurs when an exposure is associated with a systematic difference in outcome ascertainment or diagnosis. For dementia research, diagnosed health conditions that bring patients into frequent interaction with health care may increase the chance that an individual receives a dementia diagnosis.

Objective

To evaluate potential detection bias or misdiagnosis bias in evaluation of clinical factors associated with dementia using electronic health record (EHR) data.

Design, setting, and participants

This prospective cohort study used data from 2 population-based volunteer cohorts: UK Biobank (UKB) and All of Us (AOU). Participants were aged 55 years or older, were dementia-free at baseline, and had linked EHRs. Participants in UKB were followed up f

SUBMITTER: Wang J 

PROVIDER: S-EPMC12019524 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature