Tartrolon E rapidly blocks Toxoplasma gondii capacity to invade host cells.

ABSTRACT: Toxoplasmosis is a worldwide parasitic disease caused by the apicomplexan Toxoplasma gondii. Severe neurological illness occurs in immunosuppressed patients, and congenital disorders can follow transplacental primo infection during pregnancy. New effective antiparasitic drugs are needed since chronic cystic stages are resistant to current available treatments, and some of the congenital infections are unresponsive to available therapeutics. Tartrolon E (trtE) is a marine secondary metabolite that has high selectivity against human and animal apicomplexan parasites including T. gondii, Cryptosporidium parvum and Plasmodium falciparum. We evaluated the effect of the compound on extracellular tachyzoite viability, morphology, membrane permeability and its ability to block host cell attachment

SUBMITTER: Fumuso FG 

PROVIDER: S-EPMC12019577 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature