Cer(d18:1/16:0) as a biomarkers for acute coronary syndrome in Chinese populations.

ABSTRACT: Ceramides play a crucial role in atherosclerosis progression and have been linked to cardiovascular events. The objective of this study was to investigate the association between serum ceramide levels and Acute coronary syndrome, as well as evaluate their potential for predicting ACS in Chinese population. Data of 1327 patients with suspected or known coronary artery disease from Beijing anzhen Hospital and Handan First hospital were collected. Plasma ceramide were measured using the LC-MS/MS system. The area under the ROC curve was used to screen the most valuable predictor. Distinctive ACS-related variables were screened out using Boruta and LASSO regression. Multivariate Logistic models and restricted cubic spline analysis were conducted to examine the associations between Ceramide and

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12019627 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature