Cumulative Life's Essential 8 Scores and Cardiovascular Disease Risk.

ABSTRACT:

Importance

Most literature on the association between cardiovascular health (CVH) and incident cardiovascular disease (CVD) and mortality has relied on single midlife measurements. Understanding how cumulative CVH over time influences later-life CVD and mortality may aid early prevention.

Objective

To determine whether cumulative CVH, as measured by the American Heart Association Life's Essential 8 (LE8) from age 18 to 45 years, is associated with incident CVD and mortality in midlife.

Design, setting, and participants

This cohort study, the Coronary Artery Risk Development in Young Adults (CARDIA) study, collected CVH data for participants from 4 US centers from 1985 to 2020. Multivariate Cox proportional hazard models assessed the associations of (1) cumulative LE8

SUBMITTER: Walker J 

PROVIDER: S-EPMC12019673 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature