Relationship between dietary flavan-3-ols intake and mortality in metabolic syndrome population; a large cohort study.

ABSTRACT:

Background

Metabolic syndrome (MetS) is a global health concern linked to increased mortality. Diets rich in plant-derived compounds, such as polyphenols, have shown potential health benefits for MetS. Among these, flavan-3-ols, a class of commonly occurring polyphenolic compounds, are known for their antioxidant and anti-inflammatory properties. Therefore, we hypothesize that flavan-3-ols intake is negatively associated with mortality risk in MetS population.

Methods

This study analyzed NHANES data (2007-2008, 2009-2010, and 2017-2018). Flavan-3-ol and monomer intake were obtained from the USDA Flavonoid and FNDDS databases. Associations with mortality were assessed using Cox regression, survival differences were compared using Kaplan-Meier curves, and non-linear trends wer

SUBMITTER: Zhang W 

PROVIDER: S-EPMC12019991 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature