Gram-negative bacteria activate cellular pathways in plaque microenvironment; Systems biology approach.

ABSTRACT:

Background

Inflammatory events followed by bacterial infections are related to the progression of the atherosclerosis process. The study investigated the signaling and metabolic pathways of endothelial cells (ECs), macrophages (MQs), vascular smooth muscle cells (VSMCs), and dendritic cells (DCs) after exposure to Gram-negative bacterial infections. Moreover, it aimed at cross-talking and enriching the pathways on the cellular and plaque networks.

Methods and materials

High-throughput expression data series (n = 9) were selected through GEO and MAT data repositories. Upregulated differential expression genes (DEGs) were determined using R software and applied to identify the cellular signaling pathways using Enricher/Reactome tools. Then, the cell networks were visualized us

SUBMITTER: Ganjali R 

PROVIDER: S-EPMC12020080 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature