Glucagon-like peptide-1 receptor modulates cerebrospinal fluid secretion and intracranial pressure in rats.

ABSTRACT:

Background

Cerebrospinal fluid (CSF) is produced and absorbed at a balanced rate to maintain a constant intracranial pressure (ICP). The CSF dynamics are, however, disturbed in several pathological conditions, leading to elevated ICP, which may have fatal outcomes if left untreated. Treatment options for these conditions are limited to invasive neurosurgery, and novel pharmacological approaches to manage ICP in pathology are sought. Here, we aimed to demonstrate the potential of the glucagon-like peptide-1 receptor (GLP-1R) as such a target.

Methods

We administered male rats with intraperitoneal (i.p.) or intracerebroventricular (i.c.v.) GLP-1R agonist (exendin-4) or antagonist (exendin-9-39) followed by in vivo determination of CSF dynamics. GLP-1R expression in the CSF-sec

SUBMITTER: Jensen MN 

PROVIDER: S-EPMC12020230 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature